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At Embryoland, we are happy to
announce our two first clinical pregnancies in Greece following the use of the
innovative method of magnetic sperm sorting MACS® for the selection of healthy non-apoptotic
sperm in two women from Greece and Australia with a medical history of
recurrent failed IVF treatments.
Embryoland is the first IVF unit in Greece to carry out MACS® which can
be useful in cases of
- Sperm
samples with a high level of sperm DNA fragmentation
- Repeated
miscarriages with an unidentified cause
- Previous
failed IVF cycles
- Suboptimal
embryo quality when it is not attributed to oocyte quality
Please refer to your treating
doctor at Embryoland, should you wish to proceed with this technique.
What is the MACS® ART Annexin
V System?
Apoptotic sperm cells (sperm
cells that are programmed to undergo cell death) in sperm preparations decrease
the specimen quality. The MACS® ART Annexin V System is designed to allow
spermatozoa with the best characteristics to be selected for use in assisted
reproduction treatments by selectively removing apoptotic spermatozoa from
sperm preparations.
How does it work?
Annexin V recognizes the antigen EPS (externalized phosphatidylserine) in
the plasma membrane of apoptotic cells. Apoptotic cell removal begins with the magnetic
labeling of apoptotic sperm cells by the MACS® ART Annexin V
Reagent, which are tiny biodegradable magnetic particles that have an
antibody attached (the protein annexin V). The labeled sperm cells are then
passed through a separation column located in a fixed magnetic field. Unwanted
sperm cells are selectively retained in the column. Living spermatozoa are not
labeled by the reagent, so they pass through the column and are collected for
later use.
The enriched sperm populations show higher overall
quality in terms of: morphology, motility, DNA fragmentation, apoptosis,
cryosurvival rates, fertilization potential and embryo cleavage rates.
Selected references MACS® ART Annexin V System - Clinical data
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